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Ceftriaxone+Sulbactum is a combination of two antibiotic drugs, Ceftriaxone and Sulbactam. It is available in the market at Pax Healthcare under the brand name NEPA-S. NEPA-S works by stopping the formation of the bacterial protective covering which is essential for the survival of bacteria. In NEPA-S, Sulbactam is a beta-lactamase inhibitor that reduces resistance and enhances the activity of Ceftriaxone against bacteria. 

Sulbactam inhibits the action of beta-lactamase it is an enzyme produced by bacteria that can destroy antibiotics. Ceftriaxone+Sulbactum injection will be administered by a healthcare professional, so do not self-administer this drug. The common side effects of NEPA-S include pain and swelling at the injection site, skin rash,  vomiting, diarrhea, nausea, and black or bloody stools. These side effects of NEPA-S are usually mild and temporary but if these side effects persist or worsen, inform your doctor immediately. 

Medical Benefits of Ceftriaxone and Sulbactum Injection

Patients have been prescribed this combination of Ceftriaxone+Sulbactum injection to treat bacterial infections even if they have developed not stop taking NEPA-S injections and complete the full course of treatment even if you feel better because sometimes your symptoms may improve before the infection is completely cured. Inform your doctor if you don’t feel better after finishing the full course of Ceftriaxone+Sulbactum. Also, inform him/her if your symptoms are getting worse while using Ceftriaxone+Sulbactum injection.

Side Effects of Ceftriaxone and Sulbactum Injection 

There are mild to moderate side effects of Ceftriaxone+Sulbactum injection that get resolved over time. Immediately inform your doctor in case the side effects of NEPA-S persist or get severe with time. The side effects of NEPA-S may vary in all the users as they depend on the physiological conditions and response to the therapy. The range of side effects noticed on using the Ceftriaxone+Sulbactum injection are mentioned as follows:

  • Eosinophils (Increased white blood cell count),
  • Lymphocytes (Decreased white blood cell count), 
  • Low blood platelets,
  • Rash, 
  • Diarrhea, 
  • Increased liver enzymes, 
  • Allergic reaction,

Safety and Precautions 

  1. Do not consume Ceftriaxone+Sulbactum injection with alcohol as it may increase the chances of stomach bleeding. 
  1. Ceftriaxone+Sulbactum injections are not safe during pregnancy and breastfeeding, hence, do not take it without a doctor’s consultation. 
  1. Store the Ceftriaxone+Sulbactum injections in a cool and dry place away from direct sunlight. 
  1. Keep the Ceftriaxone+Sulbactum injections out of reach of children and pets. 
  1. Don’t drive or do anything that requires mental focus when taking Ceftriaxone+Sulbactum injections.

Drug Interactions

Drug-Drug Interactions: Ceftriaxone+Sulbactum injection may interact with vaccines, estrogens, aminoglycoside antibiotics, penicillin antibiotics, neomycin and gentamicin, immuno-suppressant and medicine used to treat gout.

Drug-Food Interactions: No interactions were found with NEPA-S Injection.

Drug-Disease Interactions: 

NEPA-S Injection should be used with caution in patients with kidney problems, seizures, diabetes, liver diseases, gastrointestinal diseases, and bleeding disorders. 

Drug-Drug Interactions Checker List,

Ceftriaxone+Sulbactum injection may React with a few drugs that are mentioned below,


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