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Diclofenac is a pain-relieving medicine. It is used to treat pain, swelling, stiffness, and joint pain in conditions like rheumatoid arthritis, osteoarthritis, and acute musculoskeletal injuries. It belongs to the class of medication called Non-Steroidal Anti-Inflammatory Drugs (NSAID). The medicine works by inhibiting the release of certain chemical messengers which are responsible for causing pain and inflammation. It is also used in hospital settings to prevent or treat pain following an operation. The medications work by blocking the action of the enzyme cyclooxygenase, which is required for the biosynthesis of prostaglandins.

Do not self-medicate the medicine, take it as per the dosage and duration prescribed by your doctor. Diclofenac injection should be only given by a doctor or nurse. Your healthcare provider will administer the right dose. Some people may experience side effects such as stomach pain, nausea, vomiting, heartburn, and injection site reactions. Inform your doctor if you are allergic to Diclofenac or similar medicines. 

Uses of Diclofenac Injection 

Diclofenac is an NSAID that exhibits anti-inflammatory analgesic and antipyretic activities. It involves inhibition of cyclooxygenase (COX-1 and COX-2) and it is a potent inhibitor of prostaglandin synthesis in vitro. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain and mediators of inflammation. Diclofenac is an inhibitor of prostaglandin synthesis; its mode of action may be due to a decrease in prostaglandins in peripheral tissues. Diclofenac is commonly used in the treatment of:

  • Flare-ups of joint or back pain
  • Attacks of gout
  • Pain caused by kidney stones, injuries
  • Fractures or trauma
  • Also used in hospital settings to prevent or treat pain following an operation

Side Effects of Diclofenac Injection

Mostly the side effects of Diclofenac Injection are mild to moderate and do not last for a long time. The side effects are individualistic in nature as they depend on the health condition and response to the therapy. The range of side effects noticed on using the Diclofenac Injection are mentioned below:

  • Pain, redness, lumps, feeling sick
  • discomfort sensation (application site)
  • Swelling of face, throat, and tongue, difficulty in breathing, wheezing, runny nose, and skin rashes
  • Stomach pain, indigestion, heartburn
  • Bleeding in the stomach or intestine
  • Itching, hives, bruising, painful red areas, peeling or blistering of the skin, giant wheels

Drug Interaction 

Diclofenac Injection may interact with certain medications and cause adverse health effects. The drugs can also interact with certain food items and health conditions. Do not take Diclofenac Injection with the following mentioned drugs:

  • Aspirin or ibuprofen (used for inflammation or pain)
  • Warfarin, heparin (used to treat blood clots)
  • Medicines to treat diabetes
  • Diuretics
  • Lithium, serotonin reuptake inhibitors (used to treat anxiety and depression)
  • Phenytoin (used to treat epilepsy)
  • Digoxin (used for heart problems)
  • Methotrexate, ciclosporin, pemetrexed, and tacrolimus (used for inflammation and cancers)
  • Quinolones antibiotics (used to treat some infections)
  • Steroids (used to treat the immune system)
  • Colestipol (used to reduce cholesterol)

Precautions and Warnings 

  1. Avoid consuming alcohol as it may interact with Diclofenac Injection and cause adverse health effects. 
  1. Do not take Diclofenac Injection without a doctor’s consultation if you are pregnant or lactating. 
  1. Store the medicine in a cool and dry place away from direct sunlight. 
  1. Keep the medicine out of reach of children and pets. Properly dispose of expired and discarded medicines.